Description

(E)-3-(7-Oxo-1,5,6,7-Tetrahydro-1,8-Naphthyridin-3-Yl)Acrylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its specific naphthyridine-acrylic acid hybrid structure. This compound is of significant commercial interest for its role as a critical building block in the synthesis of novel, small-molecule drug candidates targeting a range of therapeutic areas. It is primarily required by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of complex active pharmaceutical ingredients (APIs), particularly for research into kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Biochemical Research: May be utilized as a tool compound or ligand in biochemical assays to study protein-ligand interactions.
• Custom Synthesis: A starting material for the contract manufacturing of specialized, non-commercial compounds for client-specific research needs.

Basic Information

Product Name	(E)-3-(7-Oxo-1,5,6,7-Tetrahydro-1,8-Naphthyridin-3-Yl)Acrylic Acid
CAS No.	527758-08-3
Molecular Formula	C13H12N2O3
Molecular Weight	244.25 g/mol
Synonyms	(2E)-3-(7-Oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)prop-2-enoic acid; (E)-3-(7-Oxo-5,6,7,8-tetrahydro-[1,8]naphthyridin-3-yl)-acrylic acid; 3-(7-Oxo-1,5,6,7-tetrahydro-1,8-naphthyridin-3-yl)acrylic acid; 527758-08-3; 3-(7-Oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)-2-propenoic acid
EINECS	Contact for details

Quality Control

We supply (E)-3-(7-Oxo-1,5,6,7-Tetrahydro-1,8-Naphthyridin-3-Yl)Acrylic Acid in high-purity grades suitable for pharmaceutical research and development. Our products undergo rigorous quality testing to ensure batch-to-batch consistency and compliance with internal specifications. Comprehensive analytical characterization, including HPLC, NMR, and MS, is performed. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.