Description

((3,5-Dichloro-4-(3-Isopropyl-4-Methoxyphenoxy)Phenyl)Ethynyl)Trimethylsilane CAS NO 525575-59-1 is a high-purity, advanced organic intermediate featuring a unique silane-protected alkyne and a substituted diphenyl ether structure. This compound is critical for enabling complex synthetic pathways in pharmaceutical and agrochemical research, offering a protected functional handle for further cross-coupling and derivatization reactions. It is primarily sought after by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and crop protection industries for constructing novel active molecules.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and fungicides, leveraging its halogenated aromatic structure.
• Material Science Research: Acts as a monomer or precursor for advanced polymers and organic electronic materials due to its conjugated ethynyl group.
• Cross-Coupling Reactions: The trimethylsilyl-protected alkyne is a versatile reagent for Sonogashira and other palladium-catalyzed coupling reactions.
• Ligand and Catalyst Development: Provides a scaffold for creating novel phosphine or N-heterocyclic carbene ligands for asymmetric catalysis.
• Chemical Biology Probes: Utilized in the development of molecular probes and tags for studying biological systems via click chemistry.

Basic Information

Product Name	((3,5-Dichloro-4-(3-Isopropyl-4-Methoxyphenoxy)Phenyl)Ethynyl)Trimethylsilane
CAS No.	525575-59-1
Molecular Formula	C21H24Cl2O2Si
Molecular Weight	407.41 g/mol
Synonyms	Trimethyl[2-[3,5-dichloro-4-[3-(1-methylethyl)-4-methoxyphenoxy]phenyl]ethynyl]silane; 2-[3,5-Dichloro-4-(3-isopropyl-4-methoxyphenoxy)phenyl]ethynyltrimethylsilane; ((3,5-Dichloro-4-(3-isopropyl-4-methoxyphenoxy)phenyl)ethynyl)trimethylsilane; TMS-protected dichloro diphenyl ether alkyne; CAS 525575-59-1
EINECS	Contact for details

Quality Control

Our production of ((3,5-Dichloro-4-(3-Isopropyl-4-Methoxyphenoxy)Phenyl)Ethynyl)Trimethylsilane adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. Every lot is analyzed via HPLC, NMR, and GC-MS to confirm identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, supporting your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC)	≥96.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.