Description

2-Isocyano-5-Chlorbenzophenone is a versatile and highly reactive organic building block, specifically an isocyanide derivative of a chlorinated benzophenone. Its core value proposition lies in its dual functionality, serving as a key intermediate for synthesizing complex heterocyclic compounds and fine chemicals. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity intermediates for drug discovery, ligand synthesis, and the development of functional polymers.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for compounds with benzodiazepine or other fused heterocyclic scaffolds.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging its reactive isocyano group for structure diversification.
• Ligand and Catalyst Development: Serves as a valuable building block for creating specialized isocyanide-based ligands used in transition metal catalysis and organometallic chemistry.
• Material Science Research: Employed in the synthesis of functional polymers, dyes, and photoactive materials where the benzophenone moiety can impart specific light-absorbing properties.
• Multicomponent Reaction (MCR) Chemistry: An ideal substrate for Passerini and Ugi-type reactions, enabling the rapid generation of chemical libraries for high-throughput screening in drug discovery.
• Fine Chemical Production: Utilized as a specialized intermediate for manufacturing high-value, low-volume chemicals for research and niche industrial applications.

Basic Information

Product Name	2-Isocyano-5-Chlorbenzophenone
CAS No.	521270-77-9
Molecular Formula	C14H8ClNO
Molecular Weight	241.67 g/mol
Synonyms	5-Chloro-2-isocyanobenzophenone; 2-Isocyanato-5'-chlorobenzophenone; (5-Chloro-2-isocyanophenyl)(phenyl)methanone; Benzophenone, 2-isocyano-5-chloro-; 2-Isocyanobenzophenone, 5-chloro derivative
EINECS	Contact for details

Quality Control

Every batch of 2-Isocyano-5-Chlorbenzophenone is produced and tested under strict quality management protocols to ensure consistency and reliability for your synthetic processes. We provide comprehensive analytical data including HPLC purity, identity confirmation by FT-IR and NMR spectroscopy, and quantification of key impurities. A Certificate of Analysis (COA) detailing all specifications is supplied with each shipment. Our quality system is designed to support cGMP manufacturing where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its light-sensitive nature and reactive isocyano group, prolonged exposure to light, moisture, or elevated temperatures should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.