Description

5-Chloro-2-(Trifluoromethyl)Benzoic Acid Methyl Ester is a high-value trifluoromethylated aromatic building block essential for advanced organic synthesis. This compound is prized for its ability to introduce both chlorine and trifluoromethyl substituents, which are critical for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or intermediate in the development of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for cross-coupling reactions, esterifications, and further functional group transformations.
• Fluorine Chemistry: An important substrate for studying and developing new methodologies in fluorine chemistry and organofluorine compound synthesis.

Basic Information

Product Name	5-Chloro-2-(Trifluoromethyl)Benzoic Acid Methyl Ester
CAS No.	521064-74-4
Molecular Formula	C9H6ClF3O2
Molecular Weight	238.59 g/mol
Synonyms	Methyl 5-Chloro-2-(trifluoromethyl)benzoate; Benzoic acid, 5-chloro-2-(trifluoromethyl)-, methyl ester; 5-Chloro-α,α,α-trifluoro-o-toluic acid methyl ester; Methyl 5-chloro-α,α,α-trifluoro-o-toluate; 2-(Trifluoromethyl)-5-chlorobenzoic acid methyl ester
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-(Trifluoromethyl)Benzoic Acid Methyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP, ISO, and other relevant regulatory frameworks for research and commercial use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (GC)	≥97.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.