Description

Mal-Peg5-T-Butly Ester CAS NO 518044-36-5 is a functionalized polyethylene glycol (PEG) derivative featuring a maleimide group at one terminus and a tert-butyl ester at the other, connected by a pentaethylene glycol spacer. This bifunctional linker is engineered for site-specific bioconjugation, offering controlled reactivity and enhanced solubility for complex molecular assemblies. It is an essential reagent for researchers and manufacturers in pharmaceutical development, proteomics, and advanced material science, where precise and stable cross-linking is required.

Application

• Antibody-Drug Conjugate (ADC) Linker: Utilized for connecting cytotoxic payloads to monoclonal antibodies via thiol-maleimide chemistry, leveraging the PEG spacer for improved solubility and pharmacokinetics.
• Protein and Peptide Modification: Enables site-specific labeling, PEGylation, or immobilization of biomolecules for therapeutic or diagnostic applications.
• Surface Functionalization: Serves as a heterobifunctional cross-linker for modifying nanoparticles, biosensors, or chromatography matrices to create bioactive surfaces.
• Polymer Chemistry: Acts as a building block or macromonomer in the synthesis of functional, biocompatible polymers and hydrogels.
• Diagnostic Reagent Synthesis: Used in the preparation of fluorescent or enzyme-labeled probes for immunoassays and molecular imaging.
• Bioconjugation Research: A key tool in academic and industrial R&D for exploring new drug delivery systems and biomaterial constructs.

Basic Information

Item	Detail
Product Name	Mal-Peg5-T-Butly Ester
CAS No.	518044-36-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Maleimide-PEG5-t-butyl ester; 3-((2,5,8,11,14-Pentaoxahexadecan-16-yl)oxy)-3-oxopropyl)-1H-pyrrole-2,5-dione, 1-(1,1-Dimethylethyl) ester; t-Butyl ester-PEG5-maleimide; MAL-PEG5-OtBu; Heterobifunctional PEG linker, Maleimide and t-Butyl ester terminated; 1-tert-Butyl 16-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexadeca-4,7,10,13-tetraene-1,16-dioate (theoretical IUPAC-like); PEG-based crosslinker
EINECS	Contact for details

Quality Control

Our Mal-Peg5-T-Butly Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry to ensure identity and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our quality system supports compliance with cGMP and ISO standards for research and pre-clinical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under desiccant. The product is light-sensitive and may be moisture-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation. For long-term stability, store under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.