Description

Mal-Peg2-T-Butyl Ester CAS NO 518044-35-4 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a maleimide group and a protected tert-butyl ester. This compound is a critical building block in bioconjugation and pharmaceutical linker chemistry, enabling the controlled attachment of biomolecules. It is primarily utilized by researchers and manufacturers in the biopharmaceutical, diagnostic, and advanced materials sectors for creating stable, site-specific conjugates such as antibody-drug conjugates (ADCs) and PEGylated proteins.

Application

• Bioconjugation Reagent: For the site-specific coupling of thiol-containing peptides, proteins, or antibodies via the maleimide group.
• Antibody-Drug Conjugate (ADC) Linker: Serves as a key component in the synthesis of cleavable or non-cleavable linkers for targeted cancer therapies.
• PEGylation Agent: Used to modify therapeutic proteins and peptides to enhance solubility, stability, and circulation half-life.
• Diagnostic Probe Synthesis: Facilitates the labeling of biomarkers, antibodies, or nanoparticles with fluorescent dyes or other detection moieties.
• Polymer Chemistry: Acts as a functional monomer or crosslinker in the synthesis of smart hydrogels and biocompatible polymers.
• Surface Functionalization: For modifying solid supports, chips, or nanoparticles to create bioactive surfaces for assays or drug delivery.

Basic Information

Item	Details
Product Name	Mal-Peg2-T-Butyl Ester
CAS No.	518044-35-4
Molecular Formula	C17H29NO7
Molecular Weight	359.42 g/mol
Synonyms	3-Maleimidopropionic acid-PEG2-t-butyl ester; Maleimide-PEG2-t-butyl ester; 1-tert-Butyl 3-(2-(2-(3-maleimidopropanamido)ethoxy)ethyl) propanedioate; t-Butyl-PEG2-maleimide; Mal-PEG2-OtBu; Bifunctional PEG derivative (Maleimide, t-Butyl Ester); N-(t-Butoxycarbonyl-PEG2)-maleimide
EINECS	Contact for details

Quality Control

Every batch of Mal-Peg2-T-Butyl Ester is manufactured under strict quality management systems. We perform comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure the product meets the high standards required for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.