Description

Hydroxy-Peg4-T-Butyl Ester is a high-purity, functionalized polyethylene glycol derivative featuring a terminal hydroxyl group and a tert-butyl ester. This bifunctional compound is a versatile building block for the synthesis of complex molecules, offering a hydrophilic PEG spacer and orthogonal protecting groups. It is primarily utilized by researchers and manufacturers in the pharmaceutical and bioconjugation sectors for developing prodrugs, linkers, and advanced drug delivery systems.

Application

• Pharmaceutical Intermediates: A key building block for the synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutics.
• Prodrug Synthesis: Used to create water-soluble prodrugs by attaching active pharmaceutical ingredients (APIs) via the cleavable ester linkage.
• Bioconjugation Linker: Serves as a hydrophilic spacer to connect biomolecules (e.g., peptides, proteins) with drugs, dyes, or other functional entities.
• Polymer Chemistry: Acts as a functional monomer or initiator for creating specialized PEG-based copolymers with tailored properties.
• Material Science: Employed in surface modification to impart hydrophilicity and biocompatibility to materials.
• Research & Development: A valuable tool in medicinal chemistry for exploring structure-activity relationships and improving pharmacokinetic profiles.

Basic Information

Product Name	Hydroxy-Peg4-T-Butyl Ester
CAS No.	518044-32-1
Molecular Formula	C17H34O8
Molecular Weight	366.45 g/mol
Synonyms	2,5,8,11-Tetraoxatetradecan-14-oic acid, 14-(1,1-dimethylethyl) ester; 1-tert-Butyl 14-hydroxy-3,6,9,12-tetraoxatetradecan-1,14-dioate; HO-PEG4-OtBu; Hydroxy-PEG4-t-butyl ester; tert-Butyl-PEG4-alcohol; 4,7,10,13-Tetraoxahexadecanoic acid, 16-(1,1-dimethylethyl) ester; 15-Hydroxy-4,7,10,13-tetraoxapentadecanoic acid tert-butyl ester; PEG4-t-butyl ester alcohol
EINECS	Contact for details

Quality Control

Our Hydroxy-Peg4-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring consistency and reliability for your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.