Description

Hydroxy-Peg3-T-Butyl Acetate is a high-purity, functionalized polyethylene glycol (PEG) derivative featuring a terminal hydroxyl group and a tert-butyl acetate moiety. This compound is engineered to serve as a versatile building block and linker in advanced organic synthesis and bioconjugation, offering controlled hydrophilicity and a reactive handle for further modification. It is critically needed by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for developing prodrugs, polymer conjugates, and functionalized surfaces.

Application

• Pharmaceutical Linker: A key intermediate in the synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutics, facilitating the attachment of cytotoxic payloads.
• Prodrug Synthesis: Used to create water-soluble prodrugs by conjugating active pharmaceutical ingredients (APIs) via its cleavable ester and PEG spacer.
• Polymer Chemistry: Serves as a functional monomer or initiator for creating specialized PEG-based copolymers with tailored properties.
• Bioconjugation & Labeling: Enables the modification of peptides, proteins, and oligonucleotides to enhance stability, solubility, or tracking.
• Surface Functionalization: Applied in material science to modify nanoparticles, biosensors, and chromatographic media with hydrophilic, biocompatible layers.
• Cross-linking Agent: Utilized in hydrogel formation and polymer network creation due to its bifunctional reactivity.

Basic Information

Item	Details
Product Name	Hydroxy-Peg3-T-Butyl Acetate
CAS No.	518044-31-0
Molecular Formula	C15H30O7
Molecular Weight	322.40 g/mol
Synonyms	2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethyl 2-methyl-2-propanoate; 3,6,9-Trioxa-12-hydroxy-1-dodecanol 11-tert-butylacetate; tert-Butyl-PEG3-OH Acetate; HO-PEG3-t-butyl acetate; 11-(tert-Butoxy)-3,6,9-trioxaundecan-1-ol acetate; PEG3 tert-Butyl Ester Alcohol; Hydroxy-terminated PEG3 tert-butyl ester
EINECS	Contact for details

Quality Control

Our Hydroxy-Peg3-T-Butyl Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.