Description

3-Pyridinemethanol,α-1,2-Propadienyl-,(Alphas)-(9Ci) is a specialized pyridine derivative featuring a unique allene-substituted methanol side chain, making it a valuable chiral building block for advanced organic synthesis. This compound is particularly significant for its role in constructing complex molecular architectures found in pharmaceuticals and agrochemicals. It is primarily sought by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for applications in medicinal chemistry and catalysis.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral drugs.
• Agrochemical Synthesis: Used in the creation of advanced pesticide and herbicide molecules, leveraging its unique structure for enhanced biological activity.
• Ligand and Catalyst Development: Acts as a precursor for synthesizing novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of functional organic materials and liquid crystals due to its rigid, conjugated allene moiety.
• Academic and R&D Laboratories: A crucial reagent for methodological studies in organic chemistry, including cycloaddition reactions and cross-coupling protocols.

Basic Information

Product Name	3-Pyridinemethanol,α-1,2-Propadienyl-,(Alphas)-(9Ci)
CAS No.	517907-53-8
Molecular Formula	C10H9NO
Molecular Weight	159.19 g/mol
Synonyms	(αS)-α-(1,2-Propadienyl)-3-pyridinemethanol; (S)-1-(Pyridin-3-yl)-2,3-butadien-1-ol; 3-Pyridinemethanol, α-(1,2-propadienyl)-, (αS)-; (S)-3-(1-Hydroxybuta-2,3-dien-1-yl)pyridine; Allenic alcohol pyridine derivative; Chiral allene-pyridine alcohol; (S)-(-)-1-(3-Pyridyl)-1-hydroxy-1,2-butadiene
EINECS	Contact for details

Quality Control

Every batch of 3-Pyridinemethanol,α-1,2-Propadienyl-,(Alphas)-(9Ci) is produced and tested under strict quality management protocols to ensure consistency and purity for critical R&D and scale-up applications. We provide comprehensive analytical data including chiral purity (enantiomeric excess) and chemical purity by HPLC. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting identity, assay, impurity profile, and specific rotation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.