Description

2-Deoxy-α-D-Erythro-Pentopyranosyl Chloride Bis(4-Methylbenzoate) is a specialized glycosyl donor intermediate of significant importance in synthetic carbohydrate and nucleoside chemistry. Its core value lies in enabling the stereoselective construction of complex sugar moieties and modified nucleosides, which are critical for pharmaceutical research and development. This high-purity building block is essential for R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries working on antiviral agents, anticancer drugs, and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel nucleoside analogs and antiviral/antitumor prodrugs.
• Carbohydrate Chemistry: Used as a glycosyl donor in the stereocontrolled synthesis of complex oligosaccharides, glycoconjugates, and glycomimetics.
• Antiviral Drug Research: Serves as a precursor in the development of modified nucleosides targeting viral polymerases (e.g., for Hepatitis, HIV).
• Oncology Research: Intermediate for creating nucleoside-based chemotherapeutic agents and targeted cancer therapies.
• Bioconjugation & Probe Development: Facilitates the chemical labeling of biomolecules (proteins, peptides) with sugar tags for diagnostic and imaging applications.
• Process Chemistry & Scale-Up: Suitable for use in developing robust, scalable synthetic routes for active pharmaceutical ingredients (APIs).
• Academic & Institutional Research: A valuable tool for studying glycosylation mechanisms and exploring new chemical biology pathways.

Basic Information

Product Name	2-Deoxy-α-D-Erythro-Pentopyranosyl Chloride Bis(4-Methylbenzoate)
CAS No.	516511-18-5
Molecular Formula	C21H21ClO6
Molecular Weight	404.84 g/mol
Synonyms	2-Deoxy-α-D-erythro-pentopyranosyl chloride bis(4-methylbenzoate); 2-Deoxy-D-ribofuranosyl chloride 3,5-di-p-toluate; 1-Chloro-2-deoxy-3,5-di-O-(4-methylbenzoyl)-α-D-ribofuranose; 3,5-Di-O-p-toluoyl-2-deoxy-α-D-ribofuranosyl chloride; 2-Deoxy-3,5-di-O-p-toluoyl-α-D-ribofuranosyl chloride; α-D-2-Deoxyribofuranosyl chloride 3,5-bis(4-methylbenzoate); Glycosyl donor intermediate 516511-18-5
EINECS	Contact for details

Quality Control

Our 2-Deoxy-α-D-Erythro-Pentopyranosyl Chloride Bis(4-Methylbenzoate) is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for demanding synthetic applications. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each batch. We adhere to cGMP principles where applicable to support our clients' regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the primary container to prevent decomposition. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.