Description

Butanedioic Acid, (1,1-Dioxido-2(3H)-Isothiazolyl)-, Dimethyl Ester, (2S) is a high-purity, chiral sulfonamide derivative of succinic acid. This compound serves as a critical advanced pharmaceutical intermediate and a versatile building block in asymmetric synthesis. It is primarily required by R&D and production teams in the pharmaceutical and fine chemical industries for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of protease inhibitors and other biologically active molecules.
• Asymmetric Synthesis: Utilized as a building block in the preparation of complex, stereochemically defined compounds for medicinal chemistry.
• Agrochemical Research: Intermediate in the development of new, enantiomerically pure crop protection agents.
• Material Science: Potential monomer or additive for creating specialized polymers with specific functional properties.
• Chemical Biology: Probe or linker molecule in biochemical research and assay development.
• Catalyst Ligand Precursor: Starting material for the synthesis of novel chiral ligands used in homogeneous catalysis.

Basic Information

Product Name	Butanedioic Acid, (1,1-Dioxido-2(3H)-Isothiazolyl)-, Dimethyl Ester, (2S)
CAS No.	515130-06-0
Molecular Formula	C9H13NO6S
Molecular Weight	263.27 g/mol
Synonyms	(2S)-2-(1,1-Dioxido-2,3-dihydroisothiazol-2-yl)succinic acid dimethyl ester; (S)-2-(1,1-Dioxido-1,2-thiazolidin-2-yl)succinic acid dimethyl ester; Dimethyl (2S)-2-(1,1-dioxido-2,3-dihydro-1,2-thiazol-2-yl)butanedioate; (S)-2-(1,1-Dioxidoisothiazolidin-2-yl)succinic Acid Dimethyl Ester; 515130-06-0; (2S)-2-(1,1-Dioxido-1,2-thiazolidin-2-yl)butanedioic acid dimethyl ester
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up processes. Quality is verified through comprehensive analytical methods including HPLC for purity and chiral assay, NMR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.