Description

3-Chloro-5-Fluoro-4-Iodopyridine is a high-value, multi-halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. Its unique halogen pattern makes it an indispensable intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is primarily sought by research chemists and process development scientists for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used to develop novel herbicides, fungicides, and insecticides by introducing the halogenated pyridine core into lead structures.
• Material Science Research: Serves as a monomer or functionalization agent in the development of organic electronic materials, ligands for catalysis, and liquid crystals.
• Cross-Coupling Reactions: The iodine and chlorine substituents make it an excellent substrate for Suzuki, Stille, and Negishi cross-coupling reactions to create complex biaryl systems.
• Chemical Biology Probes: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and as a scaffold for labeling or probe development.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	3-Chloro-5-Fluoro-4-Iodopyridine
CAS No.	514798-07-3
Molecular Formula	C5H2ClFIN
Molecular Weight	273.43 g/mol
Synonyms	4-Iodo-3-chloro-5-fluoropyridine; 3-Chloro-5-fluoro-4-iodopyridine; 5-Fluoro-3-chloro-4-iodopyridine; Pyridine, 3-chloro-5-fluoro-4-iodo-; 3-Chloro-5-fluoro-4-iodo-pyridine; 4-Iodo-3-chloro-5-fluoro-pyridine
EINECS	Contact for details

Quality Control

Our 3-Chloro-5-Fluoro-4-Iodopyridine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP (current Good Manufacturing Practice) standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat and incompatible materials. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.