Description

2-Bromo-5-Chloro-3-Fluoro-4-Iodopyridine is a highly functionalized, multi-halogenated pyridine derivative of significant interest in advanced organic synthesis. This compound matters as a versatile and valuable building block for constructing complex molecular architectures, particularly in the pharmaceutical and agrochemical sectors. It is primarily needed by research chemists and process development scientists working on active pharmaceutical ingredients (APIs), crop protection agents, and specialty materials where precise halogen substitution patterns are critical for modulating biological activity and physicochemical properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, especially in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the preparation of advanced herbicides, fungicides, and insecticides with specific activity profiles.
• Ligand Precursor: Serves as a starting material for synthesizing complex chelating ligands used in catalysis and material science.
• Functional Material Development: Employed in the creation of organic electronic materials and liquid crystals due to its distinct electronic properties imparted by the halogen pattern.
• Cross-Coupling Reactions: The bromo and iodo substituents make it an excellent substrate for selective Suzuki, Stille, and Sonogashira cross-coupling reactions.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological systems and enzyme mechanisms.

Basic Information

Product Name	2-Bromo-5-Chloro-3-Fluoro-4-Iodopyridine
CAS No.	514798-05-1
Molecular Formula	C5HBrClFIN
Molecular Weight	335.32 g/mol
Synonyms	2-Bromo-5-chloro-3-fluoro-4-iodopyridine; 4-Iodo-2-bromo-5-chloro-3-fluoropyridine; Pyridine, 2-bromo-5-chloro-3-fluoro-4-iodo-; 514798-05-1; 2-Br-5-Cl-3-F-4-I-pyridine
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-Chloro-3-Fluoro-4-Iodopyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided for every shipment, ensuring full traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly sealed due to the compound's sensitivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.