Description

2,5-Dichloro-3-Fluoro-4-Iodo-Pyridine is a highly functionalized halogenated pyridine derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its unique multi-halogen substitution pattern makes it a versatile and valuable building block for constructing complex molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, antiviral agents, and other small-molecule drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the pyridine core provides bioactivity.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The iodine and chlorine substituents make it an excellent substrate for selective palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to introduce complex side chains.
• Chemical Research & Development: A valuable reagent for medicinal chemistry programs and method development in organic synthesis due to its orthogonal reactivity.
• Ligand Synthesis: Used to prepare novel nitrogen-containing ligands for catalysis and coordination chemistry.

Basic Information

Product Name	2,5-Dichloro-3-Fluoro-4-Iodo-Pyridine
CAS No.	514798-04-0
Molecular Formula	C5HCl2FIN
Molecular Weight	291.88 g/mol
Synonyms	4-Iodo-2,5-dichloro-3-fluoropyridine; 3-Fluoro-2,5-dichloro-4-iodopyridine; 2,5-Dichloro-3-fluoro-4-iodopyridine; Pyridine, 2,5-dichloro-3-fluoro-4-iodo-; 514798-04-0; 2,5-Dichloro-3-fluoro-4-iodo-pyridine
EINECS	Contact for details

Quality Control

Our 2,5-Dichloro-3-Fluoro-4-Iodo-Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.