Description

2-Bromo-5-Chloro-3-Fluoroisonicotinic Acid is a high-purity, multi-halogenated pyridine derivative serving as a critical advanced intermediate in modern synthetic chemistry. Its value lies in providing a versatile, functionalized scaffold for constructing complex molecules, particularly in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require precise halogen substitution patterns for structure-activity relationship (SAR) studies and lead optimization.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the halogen pattern influences bioactivity and selectivity.
• Chemical Research & Development: Serves as a versatile precursor for further functionalization (e.g., amidation, esterification) in academic and industrial R&D labs exploring new chemical entities.
• Ligand and Material Science: Potential use in the synthesis of specialized ligands for catalysis or as a monomer for creating functional polymers and advanced materials.

Basic Information

Product Name	2-Bromo-5-Chloro-3-Fluoroisonicotinic Acid
CAS No.	514798-01-7
Molecular Formula	C6H2BrClFNO2
Molecular Weight	254.44 g/mol
Synonyms	2-Bromo-5-chloro-3-fluoropyridine-4-carboxylic acid; 4-Pyridinecarboxylic acid, 2-bromo-5-chloro-3-fluoro-; 2-Bromo-5-chloro-3-fluoroisonicotinate; 2-Bromo-5-chloro-3-fluoro-4-pyridinecarboxylic acid; 514798-01-7; BCFI; 2-Br-5-Cl-3-F-isonicotinic acid
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-Chloro-3-Fluoroisonicotinic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. Due to its acid nature, handle with appropriate engineering controls.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.