Description

2-Ethynyl-4-(Trifluoromethyl)Pyridine is a high-value, multi-functional heterocyclic building block characterized by its unique combination of an ethynyl group and a trifluoromethyl substituent on a pyridine core. This compound matters for its critical role in modern synthetic chemistry, enabling the construction of complex molecules through versatile coupling reactions. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for applications in drug discovery, catalyst development, and the synthesis of functional polymers.

Application

• Pharmaceutical Intermediate: A key synthon for constructing active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Material Science Building Block: Employed in the creation of advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and conductive polymers, via Sonogashira and other cross-coupling reactions.
• Ligand Synthesis for Catalysis: Serves as a precursor for synthesizing specialized ligands used in homogeneous catalysis, including palladium-catalyzed cross-couplings.
• Chemical Biology Probe Development: Utilized in click chemistry applications to create molecular probes for studying biological processes and target engagement.
• Fluorinated Compound Library Synthesis: An essential component for medicinal chemistry teams building diverse compound libraries to explore structure-activity relationships (SAR).

Basic Information

Product Name	2-Ethynyl-4-(Trifluoromethyl)Pyridine
CAS No.	512197-90-9
Molecular Formula	C8H4F3N
Molecular Weight	171.12 g/mol
Synonyms	4-(Trifluoromethyl)-2-ethynylpyridine; 2-Ethynyl-4-trifluoromethylpyridine; 2-Ethynyl-α,α,α-trifluoro-picoline; 4-(Trifluoromethyl)-2-pyridylethyne; 2-Pyridylacetylene, 4-(trifluoromethyl)-; 2-Ethynyl-4-(trifluoromethyl)pyridine
EINECS	Contact for details

Quality Control

Our 2-Ethynyl-4-(Trifluoromethyl)Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports your R&D and scale-up processes with reliable, high-purity material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). The compound should be kept under an inert atmosphere to ensure long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.