Description

Pyridine, 2-Chloro-4,5-Difluoro- (9Ci) is a high-value, multi-functional halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it an essential intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the development of new active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders and anti-infectives.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the difluoro and chloro groups contribute to biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized nitrogen-containing ligands used in transition metal catalysis for fine chemical manufacturing.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and electronic materials requiring specific halogenated heterocyclic cores.
• Chemical Biology Probes: Utilized as a scaffold for developing molecular probes and fluorescent tags in diagnostic and life science research.

Basic Information

Product Name	Pyridine, 2-Chloro-4,5-Difluoro- (9Ci)
CAS No.	511522-70-6
Molecular Formula	C5H2ClF2N
Molecular Weight	149.53 g/mol
Synonyms	2-Chloro-4,5-difluoropyridine; 4,5-Difluoro-2-chloropyridine; 2-Chloro-4,5-difluoro-pyridine; Pyridine, 2-chloro-4,5-difluoro-; 511522-70-6 (CAS); 2-Cl-4,5-F2-Pyridine
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-4,5-difluoropyridine is produced and tested under strict quality management protocols to ensure consistency and purity for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles, typically determined by GC, HPLC, and NMR. Our quality system supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. Containers should be kept tightly sealed to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.