Description

1,4,7,10-Tetraazacyclododecane-1,4-Diacetic Acid, 1,4-Bis(1,1-Dimethylethyl) Ester is a key protected intermediate in the synthesis of sophisticated macrocyclic chelating agents. This compound is specifically engineered for the controlled functionalization of cyclen (1,4,7,10-tetraazacyclododecane) backbones, enabling the creation of high-performance ligands. It is essential for researchers and manufacturers developing next-generation contrast agents for medical imaging, radiopharmaceuticals, and catalysts for industrial processes.

Application

• Pharmaceutical Intermediate: Critical building block for synthesizing macrocyclic gadolinium-based contrast agents used in Magnetic Resonance Imaging (MRI).
• Radiopharmaceutical Precursor: Used in the development of chelators for radiolabeling with isotopes like Gallium-68 or Lutetium-177 for diagnostic and therapeutic applications.
• Catalyst Ligand Synthesis: Serves as a precursor for creating specialized ligands used in homogeneous catalysis and metal-organic frameworks (MOFs).
• Chemical Research & Development: A valuable tool in academic and industrial R&D for studying coordination chemistry and designing novel metal complexes.
• Diagnostic Reagent Development: Used in the formulation of advanced diagnostic kits and probes that require highly specific metal chelation.

Basic Information

Item	Detail
Product Name	1,4,7,10-Tetraazacyclododecane-1,4-Diacetic Acid, 1,4-Bis(1,1-Dimethylethyl) Ester
CAS No.	507475-91-4
Molecular Formula	C24H46N4O4
Molecular Weight	454.65 g/mol
Synonyms	1,4-Bis(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane; 1,4-Bis(tert-butyl acetate)-1,4,7,10-tetraazacyclododecane; 1,4-Di-Boc-DO2A; DO2A-tBu ester; 1,4,7,10-Tetraazacyclododecane-1,4-diacetic acid di-tert-butyl ester; tert-Butyl DO2A; Protected DO2A; 1,4-Bis[(tert-butoxy)carbonylmethyl]-1,4,7,10-tetraazacyclododecane
EINECS	Contact for details

Quality Control

Our 1,4,7,10-Tetraazacyclododecane-1,4-Diacetic Acid, 1,4-Bis(1,1-Dimethylethyl) Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity suitable for sensitive pharmaceutical applications. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.