Description

2-Chloro-5-(trifluoromethyl)-4-iodopyridine is a high-value, multi-functional halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring chlorine, iodine, and trifluoromethyl substituents, provides versatile reactivity for constructing complex molecular architectures. This intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting new therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents, such as herbicides and fungicides, leveraging the bioactivity of the pyridine core.
• Ligand & Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands and organocatalysts used in cross-coupling and other metal-catalyzed reactions.
• Material Science Research: Employed in the development of organic electronic materials, liquid crystals, and functional polymers due to its halogenated, electron-deficient aromatic system.
• Chemical Biology Probes: Useful for creating tagged molecules or probes for studying biological systems and mechanisms.

Basic Information

Product Name	2-Chloro-5-(Trifluoromethyl)-4-Iodopyridine
CAS No.	505084-55-9
Molecular Formula	C6H2ClF3IN
Molecular Weight	321.44 g/mol
Synonyms	4-Iodo-2-chloro-5-(trifluoromethyl)pyridine; 2-Chloro-4-iodo-5-(trifluoromethyl)pyridine; 5-(Trifluoromethyl)-2-chloro-4-iodopyridine; 2-Chloro-5-trifluoromethyl-4-iodopyridine; 4-Iodo-2-chloro-5-trifluoromethylpyridine; Pyridine, 2-chloro-5-(trifluoromethyl)-4-iodo-
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-(trifluoromethyl)-4-iodopyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.