Description

6-(2-Fluorophenyl)-Nicotinic Acid is a high-value fluorinated nicotinic acid derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring a fluorinated aromatic ring, is engineered to modulate the physicochemical and biological properties of target compounds. This intermediate is essential for research and development chemists in the pharmaceutical and agrochemical sectors, where it is utilized to create novel active ingredients with enhanced efficacy and stability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel small-molecule drugs, particularly in kinase inhibitor and central nervous system (CNS) therapeutic research.
• Agrochemical Synthesis: Used in the design and production of next-generation herbicides and fungicides, where the fluorine atom improves lipophilicity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of advanced organic materials, such as liquid crystals and organic semiconductors.
• Chemical Biology Probes: Utilized to develop fluorescent tags and molecular probes for studying biological processes.
• Custom Synthesis and Contract Manufacturing: A fundamental starting material for custom synthesis projects requiring fluorinated aromatic systems.

Basic Information

Product Name	6-(2-Fluorophenyl)-Nicotinic Acid
CAS No.	505082-91-7
Molecular Formula	C12H8FNO2
Molecular Weight	217.20 g/mol
Synonyms	2-Fluoro-6-phenylnicotinic acid; 6-(2-Fluorophenyl)pyridine-3-carboxylic acid; 3-Pyridinecarboxylic acid, 6-(2-fluorophenyl)-; 2-Fluoro-6-phenyl-3-pyridinecarboxylic acid; Nicotinic acid, 6-(2-fluorophenyl)-; 505082-91-7
EINECS	Contact for details

Quality Control

Every batch of 6-(2-Fluorophenyl)-Nicotinic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and stored in the original packaging away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.