Description

Ethyl Difluoro(6-Methylpyridin-2-Yl)Acetate is a high-value fluorinated pyridine derivative, serving as a versatile and critical building block in advanced organic synthesis. Its unique structure, featuring a difluoroacetate ester moiety adjacent to a substituted pyridine ring, makes it an essential precursor for introducing fluorinated motifs into complex molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients, where the incorporation of fluorine atoms can dramatically alter a compound's metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: Key synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, CNS agents, and anti-infectives.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where fluorinated compounds often exhibit enhanced activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing novel chelating ligands or organocatalysts containing pyridine and fluorinated groups.
• Material Science Research: Employed in the synthesis of fluorinated organic molecules for potential application in liquid crystals, organic electronics, or specialty polymers.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	Ethyl Difluoro(6-Methylpyridin-2-Yl)Acetate
CAS No.	503627-69-8
Molecular Formula	C₁₀H₁₁F₂NO₂
Molecular Weight	215.20 g/mol
Synonyms	Ethyl 2,2-difluoro-2-(6-methylpyridin-2-yl)acetate; 2,2-Difluoro-2-(6-methyl-2-pyridinyl)acetic Acid Ethyl Ester; Ethyl 2-(6-Methylpyridin-2-yl)-2,2-difluoroacetate; Acetic acid, 2,2-difluoro-2-(6-methyl-2-pyridinyl)-, ethyl ester; 2-Pyridineacetic acid, 6-methyl-, α,α-difluoro-, ethyl ester
EINECS	Contact for details

Quality Control

Every batch of Ethyl Difluoro(6-Methylpyridin-2-Yl)Acetate is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing key parameters such as assay (by HPLC/NMR), impurity profile, and physical characteristics. Our quality commitment aligns with cGMP standards where applicable, supporting its use in regulated research and development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.