Description

Difluoro-(4-Methyl-Pyridin-2-Yl)-Acetic Acid Ethyl Ester is a high-value fluorinated pyridine derivative, a crucial building block in modern synthetic chemistry. Its core value lies in its ability to introduce a difluoroacetate moiety adjacent to a substituted pyridine ring, enabling precise molecular modifications for advanced material and pharmaceutical development. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel active ingredients with optimized properties.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, where the difluoro and pyridine groups can enhance biological activity and environmental profile.
• Ligand & Catalyst Precursor: Serves as a precursor for creating specialized ligands in coordination chemistry and catalysis, useful in asymmetric synthesis and cross-coupling reactions.
• Material Science: Employed in the research and development of advanced organic materials, including liquid crystals and organic semiconductors, where fluorination improves stability and electronic properties.
• Chemical Biology Probe Synthesis: Utilized for constructing molecular probes and tags for studying biological systems and mechanisms of action.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	Difluoro-(4-Methyl-Pyridin-2-Yl)-Acetic Acid Ethyl Ester
CAS No.	503627-65-4
Molecular Formula	C10H11F2NO2
Molecular Weight	215.20 g/mol
Synonyms	Ethyl 2,2-Difluoro-2-(4-methylpyridin-2-yl)acetate; 2-(4-Methyl-2-pyridinyl)-2,2-difluoroacetic Acid Ethyl Ester; 2,2-Difluoro-2-(4-methyl-2-pyridinyl)acetic Acid Ethyl Ester; Ethyl [Difluoro(4-methyl-2-pyridinyl)methyl]acetate; Difluoro(4-methyl-2-pyridinyl)acetic Acid Ethyl Ester; 503627-65-4; Ethyl 2-(4-methylpyridin-2-yl)-2,2-difluoroacetate
EINECS	Contact for details

Quality Control

Our Difluoro-(4-Methyl-Pyridin-2-Yl)-Acetic Acid Ethyl Ester is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Store away from strong acids and incompatible materials. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (HPLC/GC-MS)	Conforms
Purity (by HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.