Description

3-Iodo-6-Methoxy-2-Trifluoromethyl-Pyridine is a high-purity, multi-functional halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring iodine, methoxy, and trifluoromethyl substituents, makes it an exceptionally versatile intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infective agents.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands in transition metal catalysis and organocatalysis, enabling novel reaction pathways.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and electronic materials that require specific halogenated aromatic components.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira, Heck) to form complex biaryl and conjugated systems.
• Fluorine Chemistry Building Block: The presence of the CF3 group provides a valuable source of fluorine for designing molecules with improved lipophilicity, bioavailability, and chemical stability.

Basic Information

Product Name	3-Iodo-6-Methoxy-2-Trifluoromethyl-Pyridine
CAS No.	503184-34-7
Molecular Formula	C7H5F3INO
Molecular Weight	318.02 g/mol
Synonyms	2-(Trifluoromethyl)-6-methoxy-3-iodopyridine; 6-Methoxy-3-iodo-2-(trifluoromethyl)pyridine; 3-Iodo-6-methoxy-2-(trifluoromethyl)pyridine; 2-Trifluoromethyl-6-methoxy-3-iodopyridine; Pyridine, 3-iodo-6-methoxy-2-(trifluoromethyl)-; 503184-34-7 (CAS); 3-Iodo-6-methoxy-2-trifluoromethylpyridine
EINECS	Contact for details

Quality Control

Every batch of 3-Iodo-6-Methoxy-2-Trifluoromethyl-Pyridine is manufactured and tested under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency meet the exacting standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.