Description

4-(5-Carboxy-Pyridin-2-Yl)-[1,4]Diazepane-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a functionalized diazepane core linked to a pyridine carboxylic acid derivative. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for the synthesis of novel therapeutic agents. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing new drug candidates, particularly in areas targeting central nervous system (CNS) disorders and other receptor-mediated pathways.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of potential drug candidates, especially those with diazepane-based pharmacophores.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and library synthesis for hit-to-lead optimization in drug discovery programs.
• Ligand Synthesis: Serves as a versatile scaffold for creating novel ligands targeting G-protein-coupled receptors (GPCRs) or enzymes.
• Chemical Biology Probes: Utilized in the development of chemical probes to study biological pathways and protein function.
• Custom Synthesis Building Block: Employed by contract research and manufacturing organizations (CRAMOs) for custom synthesis projects requiring complex heterocyclic chemistry.
• Academic Research: Used in university and institutional labs for fundamental research in organic synthesis methodology and heterocyclic chemistry.

Basic Information

Item	Details
Product Name	4-(5-Carboxy-Pyridin-2-Yl)-[1,4]Diazepane-1-Carboxylic Acid tert-Butyl Ester
CAS No.	502133-50-8
Molecular Formula	C17H23N3O4
Molecular Weight	333.39 g/mol
Synonyms	tert-Butyl 4-(5-carboxypyridin-2-yl)-1,4-diazepane-1-carboxylate; 1,4-Diazepane-1-carboxylic acid, 4-(5-carboxy-2-pyridinyl)-, 1,1-dimethylethyl ester; 4-(5-Carboxy-2-pyridinyl)-1,4-diazepane-1-carboxylic acid tert-butyl ester; 2-(1-(tert-Butoxycarbonyl)-1,4-diazepan-4-yl)isonicotinic acid; Boc-4-(5-COOH-Pyridin-2-yl)-[1,4]diazepane; N-Boc-4-(5-carboxypyridin-2-yl)homopiperazine; 502133-50-8
EINECS	Contact for details

Quality Control

Our 4-(5-Carboxy-Pyridin-2-Yl)-[1,4]Diazepane-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP and ISO guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.