Description

3-(6,7-Dihydro-2-Methyl-7-Oxo-3-Propyl-2H-Pyrazolo[4,3-D]Pyrimidin-5-Yl)-4-Ethoxy-Benzenesulfonyl Chloride is a high-purity, advanced pharmaceutical intermediate and chemical building block. This compound is critical for the synthesis of complex molecules, offering a reactive sulfonyl chloride group for selective functionalization. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within the fields of oncology and metabolic disease research.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for PDE5 inhibitors and related therapeutic compounds.
• Biochemical Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new drug candidates.
• Chemical Synthesis: Serves as a versatile precursor for creating sulfonamide derivatives, amides, and other complex organic molecules via nucleophilic substitution reactions.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and scale-up projects.
• Academic Research: Utilized in university and institutional labs for exploratory chemistry and the development of new synthetic methodologies.

Basic Information

Item	Details
Product Name	3-(6,7-Dihydro-2-Methyl-7-Oxo-3-Propyl-2H-Pyrazolo[4,3-D]Pyrimidin-5-Yl)-4-Ethoxy-Benzenesulfonyl Chloride
CAS No.	501120-42-9
Molecular Formula	C₁₉H₂₂ClN₄O₄S
Molecular Weight	437.92 g/mol
Synonyms	5-(4-Ethoxy-3-sulfonylchloridophenyl)-2-methyl-7-oxo-3-propyl-2,6,7-trihydropyrazolo[4,3-d]pyrimidine; Tadalafil Sulfonyl Chloride Intermediate; PDE5 Inhibitor Intermediate; 3-(6,7-Dihydro-2-methyl-7-oxo-3-propyl-2H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxybenzenesulfonyl chloride; 4-Ethoxy-3-(2-methyl-7-oxo-3-propyl-6,7-dihydro-2H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonyl chloride
EINECS	Contact for details

Quality Control

Our 3-(6,7-Dihydro-2-Methyl-7-Oxo-3-Propyl-2H-Pyrazolo[4,3-D]Pyrimidin-5-Yl)-4-Ethoxy-Benzenesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and chemical identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, store under an inert atmosphere such as nitrogen or argon in a cool, dry place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.