Description

5-Methyl-3-((Trimethylsilyl)ethynyl)pyridin-2-amine is a specialized pyridine derivative featuring a trimethylsilyl-protected acetylene group, serving as a key synthetic intermediate in advanced organic chemistry. This compound is valued for its role in constructing complex molecular architectures, particularly in pharmaceutical research and materials science. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in cross-coupling reactions and as a building block for active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, leveraging its functionalized pyridine core.
• Material Science Precursor: Serves as a monomer or precursor in the development of organic electronic materials and metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: The ethynyl group acts as a versatile handle for Sonogashira and other palladium-catalyzed coupling reactions to create conjugated systems.
• Ligand Synthesis: Utilized for the preparation of novel nitrogen-containing ligands for catalysis.
• Academic & Industrial R&D: A valuable reagent for methodological studies and exploring new synthetic pathways in organic chemistry.

Basic Information

Item	Detail
Product Name	5-Methyl-3-((Trimethylsilyl)ethynyl)pyridin-2-amine
CAS No.	500903-95-7
Molecular Formula	C11H18N2Si
Molecular Weight	206.36 g/mol
Synonyms	2-Amino-5-methyl-3-[(trimethylsilyl)ethynyl]pyridine; 3-((Trimethylsilyl)ethynyl)-5-methylpyridin-2-amine; 5-Methyl-3-(2-trimethylsilylethynyl)pyridin-2-amine; 2-Pyridinamine, 5-methyl-3-[(trimethylsilyl)ethynyl]-; 5-Methyl-3-(trimethylsilylethynyl)pyridin-2-amine; 5-Methyl-3-((trimethylsilyl)ethynyl)-2-aminopyridine
EINECS	Contact for details

Quality Control

Our production of 5-Methyl-3-((Trimethylsilyl)ethynyl)pyridin-2-amine adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. All materials are characterized by modern analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.