Description

1-Oxaspiro[2.5]Octane-2-Carbonitrile, (-)- is a high-value, chiral spirocyclic nitrile building block of significant interest in advanced organic synthesis. Its unique constrained spirocyclic architecture and functional handles make it a critical intermediate for constructing complex molecular frameworks with precise stereochemistry. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, asymmetric synthesis, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug candidates.
• Asymmetric Synthesis: Utilized as a building block in stereoselective reactions to introduce the spirocyclic motif and nitrile functionality into target molecules.
• Medicinal Chemistry & SAR Studies: Employed in structure-activity relationship (SAR) studies to explore novel chemical space and optimize the potency and selectivity of lead compounds.
• Agrochemical Research: Serves as an advanced intermediate in the synthesis of new herbicides, fungicides, or insecticides with potentially novel modes of action.
• Ligand and Catalyst Development: Used as a precursor for synthesizing chiral ligands or organocatalysts used in enantioselective transformations.
• Material Science Research: Investigated as a monomer or precursor for specialty polymers with unique thermal or mechanical properties derived from its rigid spiro structure.

Basic Information

Product Name	1-Oxaspiro[2.5]Octane-2-Carbonitrile, (-)-
CAS No.	500899-64-9
Molecular Formula	C8H11NO
Molecular Weight	137.18 g/mol
Synonyms	(-)-1-Oxaspiro[2.5]octane-2-carbonitrile; (2S)-1-Oxaspiro[2.5]octane-2-carbonitrile; (S)-1-Oxaspiro[2.5]octane-2-carbonitrile; 2-Cyano-1-oxaspiro[2.5]octane, (-)-; Spiro[oxirane-2,1'-cyclohexane]-2-carbonitrile, (2S)-; Chiral spirocyclic oxirane carbonitrile
EINECS	Contact for details

Quality Control

Our production of 1-Oxaspiro[2.5]Octane-2-Carbonitrile, (-)- adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analysis, including chiral HPLC for enantiomeric excess (ee) determination, NMR for structural confirmation, and purity assessment. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.