Description

1-Oxaspiro[2.5]Octane-2-Carbonitrile, (+)- is a high-purity, chiral spirocyclic building block of significant interest in advanced organic synthesis. Its unique constrained spirocyclic oxirane structure makes it a valuable precursor for constructing complex, three-dimensional molecular architectures. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, asymmetric synthesis, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in programs targeting central nervous system (CNS) disorders and other therapeutic areas.
• Asymmetric Synthesis: Utilized as a building block in stereoselective reactions to introduce the spirocyclic oxirane moiety, enabling access to enantiomerically pure compounds.
• Medicinal Chemistry & Drug Discovery: Employed in lead optimization and scaffold hopping to explore novel chemical space and improve the physicochemical properties of drug candidates.
• Agrochemical Research: Serves as an intermediate in the synthesis of novel herbicides, fungicides, or insecticides with potentially enhanced efficacy and selectivity.
• Material Science Research: Potential precursor for specialty polymers or advanced materials requiring rigid, chiral components.
• Academic & Contract Research: Used in universities and CROs (Contract Research Organizations) for methodological development and fundamental studies in organic chemistry.

Basic Information

Product Name	1-Oxaspiro[2.5]Octane-2-Carbonitrile, (+)-
CAS No.	500899-63-8
Molecular Formula	C8H11NO
Molecular Weight	137.18 g/mol
Synonyms	(+)-1-Oxaspiro[2.5]octane-2-carbonitrile; (2R,6S)-6-Oxabicyclo[3.1.0]hexane-2-carbonitrile; (+)-6-Oxabicyclo[3.1.0]hexane-2-carbonitrile; (1R,5S)-6-Oxabicyclo[3.1.0]hexane-2-carbonitrile; Spiro[oxirane-2,2'-bicyclo[3.1.0]hexane]-3-carbonitrile, (1'R,5'S)-; Chiral spirocyclic oxirane carbonitrile
EINECS	Contact for details

Quality Control

Our 1-Oxaspiro[2.5]Octane-2-Carbonitrile, (+)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.