Description

(R)-3-tert-Butoxycarbonylamino-3-Pyridin-4-Yl-Propionic Acid is a high-purity chiral building block and Boc-protected amino acid derivative. This compound is a critical intermediate in the synthesis of complex pharmaceutical molecules, particularly in the development of active pharmaceutical ingredients (APIs) and peptide-based therapeutics. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and commercial synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Serves as a protected amino acid derivative for the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and lead optimization during drug discovery programs.
• Asymmetric Synthesis: Employed as a building block for constructing molecules with defined stereochemistry in catalytic and stoichiometric asymmetric reactions.
• Bioconjugation: Can be utilized in the development of antibody-drug conjugates (ADCs) and other targeted therapeutic agents.
• Chemical Biology Probes: Acts as a precursor for synthesizing labeled compounds and probes used in biochemical and cellular assays.

Basic Information

Product Name	(R)-3-tert-Butoxycarbonylamino-3-Pyridin-4-Yl-Propionic Acid
CAS No.	500788-97-6
Molecular Formula	C13H18N2O4
Molecular Weight	266.30 g/mol
Synonyms	(R)-3-((tert-Butoxycarbonyl)amino)-3-(pyridin-4-yl)propanoic acid; (R)-Boc-4-Pyridylalanine; (R)-Boc-β-(4-Pyridyl)-alanine; (R)-N-Boc-3-(4-Pyridyl)alanine; (R)-3-(Boc-amino)-3-(4-pyridyl)propionic acid; (R)-3-(tert-Butoxycarbonylamino)-3-(4-pyridyl)propanoic acid; (R)-N-(tert-Butoxycarbonyl)-3-(4-pyridinyl)-L-alanine
EINECS	Contact for details

Quality Control

Our (R)-3-tert-Butoxycarbonylamino-3-Pyridin-4-Yl-Propionic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent specifications for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.