Description

1,4-Dioxaspiro[4.4]Nonane-2-Carboxaldehyde, (2S)- (9Ci) is a high-value chiral building block and synthetic intermediate, distinguished by its spirocyclic acetal-protected aldehyde functionality. This compound is critical for the stereoselective synthesis of complex molecules, offering precise control over three-dimensional architecture. It is primarily sought after by research and development teams in the pharmaceutical and fine chemical industries for applications in asymmetric synthesis and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, particularly in the development of antiviral, anticancer, and central nervous system (CNS) active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Used as a precursor in stereocontrolled reactions, including aldol, Grignard, and reductive amination, to construct molecules with defined stereocenters.
• Fine Chemical Production: Serves as a building block for advanced materials, specialty agrochemicals, and high-value fragrance compounds requiring specific stereochemistry.
• Academic & Industrial Research: Employed in methodological development and the exploration of new catalytic processes in organic chemistry laboratories worldwide.

Basic Information

Item	Detail
Product Name	1,4-Dioxaspiro[4.4]Nonane-2-Carboxaldehyde, (2S)- (9Ci)
CAS No.	500021-00-1
Molecular Formula	C9H14O3
Molecular Weight	170.21 g/mol
Synonyms	(2S)-1,4-Dioxaspiro[4.4]nonane-2-carboxaldehyde; (S)-1,4-Dioxaspiro[4.4]nonane-2-carbaldehyde; (S)-2-Formyl-1,4-dioxaspiro[4.4]nonane; (2S)-2-(1,3-Dioxolan-2-yl)cyclopentanecarboxaldehyde; Spirocyclic acetal aldehyde (S)-isomer
EINECS	Contact for details

Quality Control

Our 1,4-Dioxaspiro[4.4]Nonane-2-Carboxaldehyde, (2S)- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical and chiral purity, meeting the exacting standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is easily oxidized and should be handled and stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.