Description

n-(Pyridine-3-Carbonyl)-L-Proline is a specialized chiral building block and proline derivative. This compound is valued for its role as a key intermediate in the synthesis of complex pharmaceutical molecules, particularly those targeting enzymatic pathways. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of active pharmaceutical ingredients (APIs), especially for protease inhibitors and other enzyme-targeted therapies.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies and biochemical assays to investigate protein-ligand interactions.
• Peptidomimetics Development: Serves as a constrained proline analog for designing and synthesizing novel peptidomimetic compounds with enhanced metabolic stability and bioavailability.
• Asymmetric Synthesis: Employed as a chiral auxiliary or building block in stereoselective organic synthesis to introduce specific stereocenters.
• Ligand for Metal Complexes: Can be utilized in the preparation of chiral ligands for catalysis in asymmetric transformations.

Basic Information

Product Name	n-(Pyridine-3-Carbonyl)-L-Proline
CAS No.	59834-37-6
Molecular Formula	C11H10N2O3
Molecular Weight	218.21 g/mol
Synonyms	N-(Nicotinoyl)-L-proline; L-Proline, 1-(3-pyridinylcarbonyl)-; 1-(Pyridine-3-carbonyl)-L-proline; (S)-1-(Nicotinoyl)pyrrolidine-2-carboxylic acid; Nicotinoyl-L-proline; 3-Pyridinecarboxylic acid, 1-L-prolyl-; 59834-37-6; Nicotinoylproline
EINECS	Contact for details

Quality Control

Our n-(Pyridine-3-Carbonyl)-L-Proline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the high standards required for pharmaceutical research. A Certificate of Analysis (COA) detailing purity, identity, and specific test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.