Description

Nα-[(Dimethylamino)Methylene]-L-Tryptophan Methyl Ester is a protected derivative of the essential amino acid L-tryptophan, featuring a dimethylaminomethylene group at the Nα-position and a methyl ester. This compound is a crucial advanced pharmaceutical intermediate (API intermediate) used in the synthesis of complex peptides and bioactive molecules. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis teams requiring high-purity, specialized building blocks.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of peptide-based drugs and investigational new chemical entities.
• Peptide Synthesis: Serves as a protected tryptophan derivative in solid-phase and solution-phase peptide chemistry.
• Bioconjugation & Labeling: Used in the development of antibody-drug conjugates (ADCs) or fluorescent probes due to the reactive indole side chain.
• Academic & Industrial Research: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies.
• Process Chemistry: Used in scale-up and optimization of synthetic routes for target molecules in GMP and non-GMP environments.

Basic Information

Product Name	Nα-[(Dimethylamino)Methylene]-L-Tryptophan Methyl Ester
CAS No.	59824-39-4
Molecular Formula	C₁₇H₂₁N₃O₂
Molecular Weight	299.37 g/mol
Synonyms	N(alpha)-(Dimethylaminomethylene)-L-tryptophan methyl ester; L-Tryptophan, N-[(dimethylamino)methylene]-, methyl ester; Methyl N-[(dimethylamino)methylene]-L-tryptophanate; (S)-Methyl 2-((dimethylamino)methyleneamino)-3-(1H-indol-3-yl)propanoate; Dmab-Trp-OMe; Fmoc-Trp(Dmab)-OH precursor; Protected Tryptophan Methyl Ester
EINECS	Contact for details

Quality Control

Our Nα-[(Dimethylamino)Methylene]-L-Tryptophan Methyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and spectroscopic identification (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere (e.g., nitrogen or argon) after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.