Description

(S)-Methyl 2-(4-Methylphenylsulfonamido)Propanoate is a high-purity chiral sulfonamide derivative, serving as a critical synthetic intermediate. Its value lies in providing a stereochemically defined building block for the construction of complex molecules, ensuring high enantiomeric purity in final products. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of novel therapeutic agents, including enzyme inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in the production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Asymmetric Catalysis Research: Serves as a precursor or ligand in the study and development of new chiral catalysts.
• Peptidomimetics & Bioactive Molecule Construction: Integral for introducing sulfonamide and ester functionalities into designed peptide analogs and other bioactive scaffolds.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in client-specific synthesis projects.
• Academic & Industrial R&D: A valuable reagent for medicinal chemistry programs and process chemistry optimization in laboratory settings.

Basic Information

Product Name	(S)-Methyl 2-(4-Methylphenylsulfonamido)Propanoate
CAS No.	59724-69-5
Molecular Formula	C11H15NO4S
Molecular Weight	257.30 g/mol
Synonyms	(S)-Methyl 2-(p-Toluenesulfonamido)propanoate; L-Alanine, N-[(4-methylphenyl)sulfonyl]-, methyl ester; Methyl (2S)-2-[(4-methylphenyl)sulfonylamino]propanoate; (S)-Methyl N-tosylalaninate; Methyl (S)-2-(tosylamino)propanoate; Tosyl-L-alanine methyl ester; N-p-Tolylsulfonyl-L-alanine methyl ester
EINECS	Contact for details

Quality Control

Our (S)-Methyl 2-(4-Methylphenylsulfonamido)Propanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, to ensure compliance with high-purity standards for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.