Description

(6S,7R)-3',4',6,8-Tetrahydro-6',7'-Dimethoxy-2'-Methylspiro[7H-Indeno[4,5-D]-1,3-Dioxole-7,1'(2'H)-Isoquinoline]-6α,8α-Diol is a complex, high-purity spirocyclic alkaloid derivative of significant interest in advanced organic synthesis and pharmaceutical research. This compound matters as a sophisticated chiral building block, enabling the development of novel molecules with potential biological activity. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for use as a key intermediate in the synthesis of complex natural product analogs and new chemical entities.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral precursor in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) or anti-cancer targets.
• Asymmetric Synthesis: Utilized as a complex, enantiomerically pure starting material or ligand scaffold for constructing molecules with high stereochemical complexity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization campaigns to explore novel chemical space.
• Natural Product Analog Synthesis: Acts as a core structure for synthesizing analogs of complex isoquinoline or indenodioxole-based natural products.
• Process Chemistry Development: Used in scaling up synthetic routes for potential drug candidates, requiring high chemical purity and consistent quality.
• Reference Standard: Supplied as a high-purity analytical standard for method development and quality control in research laboratories.

Basic Information

Product Name	(6S,7R)-3',4',6,8-Tetrahydro-6',7'-Dimethoxy-2'-Methylspiro[7H-Indeno[4,5-D]-1,3-Dioxole-7,1'(2'H)-Isoquinoline]-6α,8α-Diol
CAS No.	59654-07-8
Molecular Formula	C23H25NO6
Molecular Weight	411.45 g/mol
Synonyms	6α,8α-Dihydroxy-6',7'-dimethoxy-2'-methylspiro[7H-indeno[4,5-d][1,3]dioxole-7,1'(2'H)-isoquinoline]; Spiro[7H-indeno[4,5-d]-1,3-dioxole-7,1'(2'H)-isoquinoline]-6α,8α-diol, 3',4',6,8-tetrahydro-6',7'-dimethoxy-2'-methyl-, (6S,7R)-; (6S,7R)-Tetrahydrodimethoxymethylspiro[indeno-dioxole-isoquinoline]diol; CAS 59654-07-8
EINECS	Contact for details

Quality Control

Our (6S,7R)-3',4',6,8-Tetrahydro-6',7'-Dimethoxy-2'-Methylspiro[7H-Indeno[4,5-D]-1,3-Dioxole-7,1'(2'H)-Isoquinoline]-6α,8α-Diol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with research-grade specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >95% by HPLC), and impurity profile is provided with every shipment to guarantee traceability and support your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.