Description

D-Alanine tert-Butyl Ester Hydrochloride is a protected amino acid derivative essential for advanced organic synthesis. This high-purity chiral building block is critical for ensuring the stereochemical integrity and yield of complex target molecules. It is primarily utilized by pharmaceutical R&D and process chemistry teams for the production of active pharmaceutical ingredients (APIs), peptides, and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel APIs, particularly in antiviral and antibacterial drug development.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate D-alanine residues, crucial for creating peptides with specific biological activity and stability.
• Protecting Group Strategy: The tert-butyl ester group provides orthogonal protection for the carboxylic acid functionality during multi-step synthetic sequences.
• Chemical Biology Research: Employed in the design and synthesis of enzyme inhibitors, probes, and other bioactive molecules for mechanistic studies.
• Process Chemistry & Scale-up: Serves as a reliable starting material for the kilogram-scale production of advanced intermediates under GMP conditions.
• Asymmetric Synthesis: Utilized in catalytic asymmetric reactions to construct complex molecular architectures with high enantiomeric purity.

Basic Information

Product Name	D-Alanine tert-Butyl Ester Hydrochloride
CAS No.	59531-86-1
Molecular Formula	C7H16ClNO2
Molecular Weight	181.66 g/mol
Synonyms	(R)-2-Aminopropanoic acid 1,1-dimethylethyl ester hydrochloride; D-2-((tert-Butoxycarbonyl)amino)propanoic acid hydrochloride; tert-Butyl D-alaninate hydrochloride; (R)-tert-Butyl alaninate hydrochloride; D-Alanine O-tert-butyl ester HCl; Boc-D-Ala-OtBu·HCl; Alanine, N-Boc-D-, tert-butyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our D-Alanine tert-Butyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and production. A Certificate of Analysis (COA) detailing identity, purity (typically >98%), chiral excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and must be handled under dry, inert conditions to maintain stability and purity. The storage area should be well-ventilated.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.