Description

5-(Trimethylsilyl)Uracil is a key silylated nucleobase derivative, primarily used as a versatile building block in organic synthesis and pharmaceutical research. Its value lies in the trimethylsilyl (TMS) protecting group, which enhances solubility and stability, enabling precise chemical modifications of the uracil core. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries, particularly for developing novel nucleoside analogs and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of modified nucleosides and nucleotides for antiviral and anticancer drug development.
• Oligonucleotide Synthesis: Used as a protected monomer in the solid-phase synthesis of DNA and RNA analogs for therapeutic and diagnostic applications.
• Chemical Research: Serves as a versatile building block in organic synthesis for introducing the uracil moiety into complex molecular architectures.
• Agrochemical Development: Employed in the research and synthesis of novel pesticides and herbicides that target specific biological pathways.
• Material Science: Potential use in the creation of functionalized polymers and advanced materials with specific nucleobase properties.

Basic Information

Product Name	5-(Trimethylsilyl)Uracil
CAS No.	59523-07-8
Molecular Formula	C7H12N2O2Si
Molecular Weight	184.27 g/mol
Synonyms	5-(Trimethylsilyl)-2,4(1H,3H)-pyrimidinedione; 5-TMS-Uracil; 1H-Pyrimidine-2,4-dione, 5-(trimethylsilyl)-; Uracil, 5-(trimethylsilyl)-; 5-Trimethylsilyluracil; 5-(Trimethylsilyl)-1H-pyrimidine-2,4-dione
EINECS	Contact for details

Quality Control

Our 5-(Trimethylsilyl)Uracil is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR), to ensure it meets the high standards required for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and may require storage under an inert atmosphere for long-term preservation to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.