Description

8-Chloro-6-(2-Fluorophenyl)-1-Methyl-4H-Imidazo[1,5-A][1,4]Benzodiazepine 2,5-Dioxide is a high-purity, advanced pharmaceutical intermediate of significant interest in modern medicinal chemistry. Its complex heterocyclic structure, featuring a fused imidazobenzodiazepine core, makes it a critical building block for the research and development of novel therapeutic agents. This compound is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of specialized active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel benzodiazepine-derived active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and the development of new CNS-targeting drug candidates.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of complex heterocyclic molecules.
• Biochemical Research: Investigated for its interaction with various biological receptors and enzymes in pharmacological studies.
• Custom Synthesis: A starting material for the contract manufacturing of specialized, low-volume fine chemicals for clinical trials.

Basic Information

Product Name	8-Chloro-6-(2-Fluorophenyl)-1-Methyl-4H-Imidazo[1,5-A][1,4]Benzodiazepine 2,5-Dioxide
CAS No.	59468-87-0
Molecular Formula	C18H13ClFN3O2
Molecular Weight	357.77 g/mol
Synonyms	8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine-2,5-dione; 8-Chloro-6-(o-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine-2,5-dioxide; Imidazo[1,5-a][1,4]benzodiazepine-2,5-dioxide, 8-chloro-6-(2-fluorophenyl)-1-methyl-; CAS 59468-87-0; 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine 2,5-dioxide
EINECS	Contact for details

Quality Control

Our 8-Chloro-6-(2-Fluorophenyl)-1-Methyl-4H-Imidazo[1,5-A][1,4]Benzodiazepine 2,5-Dioxide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a well-ventilated area and protected from moisture. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.