Description

7-Chloro-5-(2-Fluorophenyl)-2-(n-Nitrosomethylamino)-3H-1,4-Benzodiazepine is a high-purity, specialized benzodiazepine derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical chemical intermediate for synthesizing novel active pharmaceutical ingredients (APIs) and for conducting detailed pharmacological studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on neuropharmacology and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel benzodiazepine-based active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new therapeutic agents targeting the central nervous system.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Biochemical Research: Employed in vitro studies to investigate ligand-receptor interactions, particularly with GABAA receptors.
• Process Development: Utilized in scaling up and optimizing synthetic routes for complex pharmaceutical molecules.

Basic Information

Product Name	7-Chloro-5-(2-Fluorophenyl)-2-(n-Nitrosomethylamino)-3H-1,4-Benzodiazepine
CAS No.	59467-62-8
Molecular Formula	C16H12ClFN4O
Molecular Weight	330.74 g/mol
Synonyms	7-Chloro-5-(2-fluorophenyl)-2-(N-nitrosomethylamino)-3H-1,4-benzodiazepine; 2-(N-Nitroso-N-methylamino)-7-chloro-5-(2-fluorophenyl)-3H-1,4-benzodiazepine; N-Methyl-N-nitroso-7-chloro-5-(2-fluorophenyl)-1,4-benzodiazepin-2-amine; Ro 07-9953; 1,4-Benzodiazepine, 7-chloro-5-(2-fluorophenyl)-2-(methylnitrosoamino)-; 7-Chloro-5-(o-fluorophenyl)-2-(N-nitrosomethylamino)-3H-1,4-benzodiazepine
EINECS	Contact for details

Quality Control

Our 7-Chloro-5-(2-Fluorophenyl)-2-(n-Nitrosomethylamino)-3H-1,4-Benzodiazepine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with the standards expected for pharmaceutical research materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.