Description

2-Bromo-6-(Trimethylsilyl)Pyridine is a versatile organosilicon-substituted pyridine derivative that serves as a key synthetic intermediate. Its value lies in the combination of a reactive bromine substituent and a protective, modifiable trimethylsilyl group, enabling precise molecular construction. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for constructing complex heterocyclic frameworks and functionalized ligands.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting the central nervous system and other therapeutic areas.
• Agrochemical Synthesis: Used in the development of novel pesticides, herbicides, and fungicides, leveraging its pyridine core for biological activity.
• Ligand Precursor in Catalysis: Serves as a starting material for synthesizing sophisticated nitrogen-containing ligands used in transition metal catalysis for fine chemical production.
• Material Science Research: Employed in the creation of organic semiconductors, liquid crystals, and other functional materials where the silyl group aids in solubility and processability.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl systems.
• Chemical Derivatization: The trimethylsilyl group can be selectively modified or removed, allowing for sequential functionalization strategies in complex molecule synthesis.

Basic Information

Item	Detail
Product Name	2-Bromo-6-(Trimethylsilyl)Pyridine
CAS No.	59409-80-2
Molecular Formula	C8H12BrNSi
Molecular Weight	230.18 g/mol
Synonyms	6-Bromo-2-(trimethylsilyl)pyridine; 2-(Trimethylsilyl)-6-bromopyridine; 6-Bromo-2-pyridyltrimethylsilane; 2-Bromo-6-trimethylsilylpyridine; 2-Bromo-6-TMS-pyridine; Pyridine, 2-bromo-6-(trimethylsilyl)-; (6-Bromo-2-pyridinyl)trimethylsilane
EINECS	Contact for details

Quality Control

Our production of 2-Bromo-6-(Trimethylsilyl)Pyridine adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We employ advanced analytical techniques including GC, HPLC, and NMR for comprehensive characterization. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.