Description

17β-[(Trimethylsilyl)Oxy]Estr-5(10)-En-3-One is a high-purity, advanced steroid intermediate featuring a strategically protected hydroxyl group. This compound is critical for the efficient synthesis of complex steroid-based pharmaceuticals and research compounds, offering a stable and reactive handle for further chemical transformations. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers specializing in hormone derivatives and steroid chemistry.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of steroidal active pharmaceutical ingredients (APIs) and novel drug candidates.
• Research & Development: Used in academic and industrial research for studying steroid metabolism, receptor binding, and developing new therapeutic agents.
• Process Chemistry: Employed in the development and scale-up of synthetic routes for estrane and gonane series steroids.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and quality control in steroid manufacturing.

Basic Information

Product Name	17β-[(Trimethylsilyl)Oxy]Estr-5(10)-En-3-One
CAS No.	59384-55-3
Molecular Formula	C22H36O2Si
Molecular Weight	360.61 g/mol
Synonyms	17β-[(Trimethylsilyl)oxy]estr-5(10)-en-3-one; 3-Oxo-5(10)-estren-17β-ol trimethylsilyl ether; 17β-Trimethylsilyloxy-5(10)-estren-3-one; Estr-5(10)-en-3-one, 17-[(trimethylsilyl)oxy]-, (17β)-; 5(10)-Estren-3-one, 17β-[(trimethylsilyl)oxy]-; TMS-Estrone Derivative
EINECS	Contact for details

Quality Control

Our 17β-[(Trimethylsilyl)Oxy]Estr-5(10)-En-3-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.