Description

(R)-n-Boc-Glutamic Acid-1,5-Dimethyl Ester is a high-purity, enantiomerically pure chiral building block essential for advanced organic synthesis. This compound is a key protected intermediate for the controlled introduction of the (R)-glutamic acid moiety into complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of peptide-based therapeutics, enzyme inhibitors, and other bioactive molecules. Its defined stereochemistry and protective groups provide critical control over reaction pathways and final product purity.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel Active Pharmaceutical Ingredients (APIs), particularly in peptide and peptidomimetic drug discovery.
• Peptide Chemistry: Serves as a protected (R)-glutamate residue for the solid-phase and solution-phase synthesis of stereochemically defined peptides.
• Protease Inhibitor Development: Used in the research and production of inhibitors targeting glutamate-specific proteases.
• Chemical Biology Probes: Employed in the creation of labeled or modified amino acid derivatives for studying biological processes.
• Asymmetric Synthesis: Acts as a starting material or intermediate for the preparation of other non-natural chiral amino acids and derivatives.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	(R)-n-Boc-Glutamic Acid-1,5-Dimethyl Ester
CAS No.	59279-60-6
Molecular Formula	C₁₂H₂₁NO₆
Molecular Weight	275.30 g/mol
Synonyms	(R)-1,5-Dimethyl 1-(tert-butoxycarbonyl)glutamate; (R)-Boc-Glu(OMe)-OMe; (R)-N-(tert-Butoxycarbonyl)glutamic Acid Dimethyl Ester; (R)-Boc-Glutamic Acid Dimethyl Ester; (R)-2-((tert-Butoxycarbonyl)amino)pentanedioic Acid 1,5-Dimethyl Ester; (R)-N-Boc-glutamic Acid Dimethyl Ester; (R)-Boc-Glu(OMe)₂; (R)-N-Boc-L-glutamic Acid Dimethyl Ester
EINECS	Contact for details

Quality Control

Our (R)-n-Boc-Glutamic Acid-1,5-Dimethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity (HPLC), chemical purity (HPLC), and identity confirmation (IR, NMR) to ensure it meets the high standards required for pharmaceutical research. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.