Description

cis-Piperidine-2,6-Dicarboxylic Acid Dimethyl Ester is a high-purity, versatile chiral building block and synthetic intermediate of significant importance in advanced organic synthesis. Its constrained piperidine dicarboxylate structure makes it a valuable precursor for the development of pharmaceuticals, agrochemicals, and sophisticated ligands for catalysis. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, fine chemical, and academic research sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key chiral scaffold in the synthesis of active pharmaceutical ingredients (APIs), particularly for neurologic and metabolic drugs.
• Ligand Synthesis: Precursor for creating novel chiral ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Fine Chemical Building Block: Used in the multi-step synthesis of complex natural products and specialty agrochemicals.
• Academic & Industrial Research: Serves as a standard or starting material in methodological development and medicinal chemistry programs.
• Peptidomimetic Chemistry: The constrained ring system is utilized to design and synthesize peptide analogs with enhanced stability and bioavailability.

Basic Information

Product Name	cis-Piperidine-2,6-Dicarboxylic Acid Dimethyl Ester
CAS No.	59234-46-7
Molecular Formula	C9H15NO4
Molecular Weight	201.22 g/mol
Synonyms	Dimethyl cis-2,6-piperidinedicarboxylate; (2R,6S)-2,6-Piperidinedicarboxylic acid dimethyl ester; (2S,6R)-2,6-Piperidinedicarboxylic acid dimethyl ester; cis-2,6-Dimethoxycarbonylpiperidine; L-2,6-Dicarbomethoxypiperidine (cis); Piperidine-2,6-dicarboxylic acid dimethyl ester, cis-; NSC 334903; (2R,6S)-rel-2,6-Piperidinedicarboxylic Acid Dimethyl Ester
EINECS	Contact for details

Quality Control

Our cis-Piperidine-2,6-Dicarboxylic Acid Dimethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (ee, HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.