Description

(R)-4-Hydroxy-6'-Methoxy-6-Methyl-3,4'-Dioxospiro[Benzofuran-2(3H),1'-[2,5]Cyclohexadiene]-2'-Carboxylic Acid Methyl Ester is a high-purity chiral spirocyclic compound with significant synthetic utility. This advanced pharmaceutical intermediate is valued for its complex molecular architecture, which serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs). It is primarily required by research institutions and manufacturers in the pharmaceutical and fine chemical industries for developing novel therapeutic agents and conducting process chemistry research.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Used in research and development for constructing stereochemically defined complex organic molecules.
• Medicinal Chemistry Research: Serves as a key scaffold or precursor in the discovery and optimization of new chemical entities for therapeutic applications.
• Process Chemistry Development: Employed in scaling up synthetic routes for pharmaceutical manufacturing under GMP conditions.
• Fine Chemical Synthesis: Utilized in the production of specialty chemicals requiring high stereochemical purity.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in pharmaceutical labs.

Basic Information

Product Name	(R)-4-Hydroxy-6'-Methoxy-6-Methyl-3,4'-Dioxospiro[Benzofuran-2(3H),1'-[2,5]Cyclohexadiene]-2'-Carboxylic Acid Methyl Ester
CAS No.	59187-35-8
Molecular Formula	C18H16O7
Molecular Weight	344.32 g/mol
Synonyms	(R)-4-Hydroxy-6'-methoxy-6-methyl-3,4'-dioxospiro[benzofuran-2(3H),1'-[2,5]cyclohexadiene]-2'-carboxylic acid methyl ester; Methyl (R)-4-hydroxy-6'-methoxy-6-methyl-3,4'-dioxospiro[benzofuran-2(3H),1'-[2,5]cyclohexadiene]-2'-carboxylate; (R)-enantiomer of the spirocyclic benzofuran-dione; CAS 59187-35-8; Spiro[benzofuran-2(3H),1'-[2,5]cyclohexadiene]-2'-carboxylic acid, 4-hydroxy-6'-methoxy-6-methyl-3,4'-dioxo-, methyl ester, (R)-; (R)-Methyl 4-hydroxy-6'-methoxy-6-methyl-3,4'-dioxospiro[benzofuran-2(3H),1'-[2,5]cyclohexadiene]-2'-carboxylate
EINECS	Contact for details

Quality Control

Our (R)-4-Hydroxy-6'-Methoxy-6-Methyl-3,4'-Dioxospiro[Benzofuran-2(3H),1'-[2,5]Cyclohexadiene]-2'-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.