Description

(+)-4-Hydroxy-6'-Methoxy-6-Methyl-3,4'-Dioxospiro[Benzofuran-2(3H),1'-[2,5]Cyclohexadiene]-2'-Carboxylic Acid Methyl Ester is a high-purity, optically active spirocyclic compound characterized by its complex benzofuran and cyclohexadiene fused structure. This compound is a critical advanced pharmaceutical intermediate and a valuable scaffold in synthetic organic chemistry for developing novel bioactive molecules. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical, agrochemical, and fine chemical industries for its utility in constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of potential drug candidates, particularly for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Research: Used in the development of novel, high-performance active ingredients for crop protection products.
• Organic Synthesis: Acts as a versatile precursor for synthesizing complex natural product analogs and other spirocyclic compounds.
• Chemical Biology Probe Development: Utilized as a core structure for creating molecular probes to study enzyme function and biological pathways.
• Material Science Research: Investigated as a monomer or precursor for specialty polymers with unique optical or electronic properties.

Basic Information

Product Name	(+)-4-Hydroxy-6'-Methoxy-6-Methyl-3,4'-Dioxospiro[Benzofuran-2(3H),1'-[2,5]Cyclohexadiene]-2'-Carboxylic Acid Methyl Ester
CAS No.	59092-96-5
Molecular Formula	C18H16O7
Molecular Weight	344.32 g/mol
Synonyms	(+)-Methyl 4-Hydroxy-6'-Methoxy-6-Methyl-3,4'-dioxospiro[benzofuran-2(3H),1'-[2,5]cyclohexadiene]-2'-carboxylate; (6'R)-4-Hydroxy-6'-Methoxy-6-Methyl-3,4'-dioxospiro[1-benzofuran-2(3H),1'-[2,5]cyclohexadiene]-2'-carboxylic Acid Methyl Ester; Spiro[benzofuran-2(3H),1'-[2,5]cyclohexadiene]-2'-carboxylic Acid Derivative; (+)-Spirocyclic Benzofuranone Ester; Methyl (6'R)-4-Hydroxy-6'-methoxy-6-methyl-3,4'-dioxospiro[1-benzofuran-2(3H),1'-[2,5]cyclohexadiene]-2'-carboxylate
EINECS	Contact for details

Quality Control

Our production of (+)-4-Hydroxy-6'-Methoxy-6-Methyl-3,4'-Dioxospiro[Benzofuran-2(3H),1'-[2,5]Cyclohexadiene]-2'-Carboxylic Acid Methyl Ester adheres to stringent in-process controls and final release testing to ensure consistent purity and enantiomeric excess. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We operate under a cGMP-compliant quality management system, ensuring traceability and reliability for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.