Description

2-Methylbutyric Acid 8-[2-(4-Hydroxy-6-Oxotetrahydro-2H-Pyran-2-Yl)Ethyl]-7-Methyl-1,2,3,7,8,8A-Hexahydronaphthalen-1-Yl Ester is a high-purity, complex organic ester with a specific stereochemical configuration. This compound is valued for its role as a key chiral intermediate in the synthesis of advanced pharmaceutical active ingredients and fine chemicals. It is primarily needed by pharmaceutical R&D laboratories, process development chemists, and manufacturers of high-value agrochemicals and fragrances who require precise molecular building blocks.

Application

• Pharmaceutical Intermediate: Critical chiral precursor in the synthesis of complex therapeutic agents, particularly in steroid and terpenoid-based drug development.
• Asymmetric Synthesis: Used as a building block in stereoselective chemical reactions to construct molecules with specific three-dimensional orientations.
• Fine Chemical Production: Serves as a specialized intermediate for manufacturing high-value agrochemicals, flavors, and fragrance ingredients.
• Research & Development: Essential compound for academic and industrial research in organic chemistry, medicinal chemistry, and total synthesis projects.
• Process Chemistry: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Reference Standard: Used as an analytical standard for quality control and method development in HPLC and GC analysis within regulated industries.

Basic Information

Product Name	2-Methylbutyric Acid 8-[2-(4-Hydroxy-6-Oxotetrahydro-2H-Pyran-2-Yl)Ethyl]-7-Methyl-1,2,3,7,8,8A-Hexahydronaphthalen-1-Yl Ester
CAS No.	58948-09-7
Molecular Formula	C24H36O5
Molecular Weight	404.54 g/mol
Synonyms	8-[2-(4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2-methylbutanoate; (8R,8aS)-8-[2-[(2S,4S)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2-methylbutanoate; 2-Methylbutyric Acid Ester with a Hexahydronaphthalenol Derivative; A key intermediate for Atorvastatin; Lactone side-chain intermediate; Atorvastatin Lactone Intermediate; (4R,6R)-6-((S)-2-((2S,4S)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-2,2-dimethyl-1,3-dioxane-4-acetic Acid Derivative
EINECS	Contact for details

Quality Control

Our 2-Methylbutyric Acid 8-[2-(4-Hydroxy-6-Oxotetrahydro-2H-Pyran-2-Yl)Ethyl]-7-Methyl-1,2,3,7,8,8A-Hexahydronaphthalen-1-Yl Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets the exacting standards required for pharmaceutical synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for full traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere when appropriate to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.