Description

Cyclopropyl Isocyanide is a versatile and highly reactive organic building block characterized by its strained three-membered cyclopropyl ring and an isocyanide functional group. This unique structure makes it a valuable synthon for constructing complex heterocyclic frameworks and fine chemicals. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly for creating nitrogen-containing heterocycles common in active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, leveraging its reactivity to introduce the cyclopropyl moiety into active molecules.
• Material Science Research: Employed in the development of advanced polymers, ligands, and metal-organic frameworks (MOFs) due to its strong coordinating and reactive properties.
• Multicomponent Reactions (MCRs): An essential reactant in Passerini and Ugi-type reactions for the efficient, one-pot synthesis of complex amides and peptide-like structures.
• Catalysis & Ligand Design: Serves as a precursor for designing novel isocyanide-based ligands used in transition metal catalysis.
• Chemical Biology Probes: Utilized in bioorthogonal chemistry and for labeling biomolecules, aiding in proteomics and diagnostic research.

Basic Information

Product Name	Cyclopropyl Isocyanide
CAS No.	58644-53-4
Molecular Formula	C4H5N
Molecular Weight	67.09 g/mol
Synonyms	Cyclopropane, isocyano-; Isocyanocyclopropane; Cyclopropylisonitrile; Cyclopropyl isonitrile; Cyclopropanyl isocyanide; (Isocyanomethyl)cyclopropane; 1-Isocyanocyclopropane
EINECS	Contact for details

Quality Control

Our Cyclopropyl Isocyanide is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles. We adhere to cGMP principles for research-grade chemicals to support our customers in regulated development environments.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile and light-sensitive nature, store in a cool, well-ventilated place at 2-8°C (refrigerated) or as specified on the label. Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation and minimize evaporation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.