Description

4-Oxo-2S-[[(Phenymethyoxy)Carbonyl]Amino]-Butyric Acid Phenymethyl Ester is a high-purity chiral building block and protected amino acid derivative essential for advanced organic synthesis. This compound is valued for its role in constructing complex peptide backbones and other biologically active molecules with precise stereochemical control. It is a critical intermediate for pharmaceutical R&D, particularly in the development of protease inhibitors, peptide-based therapeutics, and other fine chemicals requiring high enantiomeric purity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), especially protease inhibitors and peptide drugs.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected glutamic acid or aspartic acid analog.
• Bioconjugation & Linker Chemistry: Serves as a precursor for creating specialized linkers in antibody-drug conjugates (ADCs) and prodrugs.
• Chemical Biology Research: Employed in the design and synthesis of enzyme substrates, inhibitors, and molecular probes for biochemical studies.
• Asymmetric Synthesis: Acts as a starting material or auxiliary in catalytic asymmetric reactions to introduce chiral centers.
• Fine Chemical Production: Utilized in the custom synthesis of complex organic molecules for agrochemical and material science applications.

Basic Information

Product Name	4-Oxo-2S-[[(Phenymethyoxy)Carbonyl]Amino]-Butyric Acid Phenymethyl Ester
CAS No.	58578-45-3
Molecular Formula	C20H21NO6
Molecular Weight	371.39 g/mol
Synonyms	(Z)-4-Oxo-2-[[(benzyloxy)carbonyl]amino]-2-butenoic acid phenylmethyl ester; N-Cbz-L-Aspartic Acid 4-Benzyl Ester; Nα-Cbz-L-Aspartic Acid β-Benzyl Ester; (Z)-2-(((Benzyloxy)carbonyl)amino)-4-oxobut-2-enoic acid benzyl ester; L-Aspartic acid, N-[(phenylmethoxy)carbonyl]-, 4-phenylmethyl ester; Benzyl N-[(benzyloxy)carbonyl]-L-aspart-4-ate; Cbz-Asp(OBzl)-OH (common abbreviation)
EINECS	Contact for details

Quality Control

Our 4-Oxo-2S-[[(Phenymethyoxy)Carbonyl]Amino]-Butyric Acid Phenymethyl Ester is manufactured under strict quality systems to ensure batch-to-batch consistency for critical research and production. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to meet the stringent requirements of pharmaceutical development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Enantiomeric Excess)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.