Description

Diethyl L-2-Isothiocyantoglutarate is a specialized chiral building block and synthetic intermediate of significant importance in fine chemical synthesis. Its value lies in its unique molecular structure, which incorporates both an isothiocyanate group and a glutarate ester, enabling its use in the construction of complex, biologically active molecules. This high-purity compound is essential for research and production within the pharmaceutical, agrochemical, and advanced material sectors, where precise stereochemistry and functional group compatibility are critical.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in the development of protease inhibitors and other targeted therapies.
• Peptide Mimetics & Conjugation: Utilized in the preparation of peptide analogs and for the site-specific conjugation of payloads in bioconjugation chemistry, leveraging the reactive isothiocyanate group.
• Agrochemical Research: Serves as a building block for creating new active ingredients with specific stereochemical requirements for enhanced efficacy and selectivity.
• Ligand & Catalyst Development: Employed in the synthesis of chiral ligands and organocatalysts for asymmetric synthesis applications.
• Chemical Biology Probes: Used to create isothiocyanate-functionalized probes for labeling and studying biological systems.
• Advanced Material Synthesis: A precursor for specialty polymers and dendrimers requiring specific functional group integration.

Basic Information

Product Name	Diethyl L-2-Isothiocyantoglutarate
CAS No.	58560-28-4
Molecular Formula	C10H15NO5S
Molecular Weight	261.30 g/mol
Synonyms	L-2-Isothiocyanatoglutaric Acid Diethyl Ester; Diethyl (2S)-2-Isothiocyanatopentanedioate; (S)-Diethyl 2-Isothiocyanatoglutarate; Diethyl L-2-Isothiocyanatoglutarate; Glutaric acid, 2-isothiocyanato-, diethyl ester, (S)-; L-2-Isothiocyanatoglutaric Acid Diethyl Ester; (S)-2-Isothiocyanatoglutaric Acid Diethyl Ester
EINECS	Contact for details

Quality Control

Our Diethyl L-2-Isothiocyantoglutarate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, identity confirmation by IR and NMR spectroscopy, and precise assay determination. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure full traceability and compliance with your research or cGMP-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed under an inert atmosphere after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.