Description

4-(Difluoromethoxy)Phenyl Isocyanate is a specialized aromatic isocyanate monomer featuring a difluoromethoxy substituent. This compound is valued for its role as a key building block in the synthesis of advanced polymers and agrochemicals, where its unique structure imparts desirable properties like chemical resistance and thermal stability. It is primarily sought by R&D chemists and process engineers in the pharmaceutical, agrochemical, and high-performance materials industries for creating novel urethane linkages and heterocyclic compounds.

Application

• Agrochemical Intermediate: A critical precursor in the synthesis of modern pesticides and herbicides, where the difluoromethoxy group enhances biological activity and environmental stability.
• Pharmaceutical Building Block: Used in medicinal chemistry to develop active pharmaceutical ingredients (APIs), particularly for constructing urea and carbamate derivatives with targeted therapeutic effects.
• Polymer & Resin Modification: Serves as a functional monomer for producing specialized polyurethanes, polyureas, and coatings with improved weatherability, low surface energy, and chemical resistance.
• Cross-linking Agent: Employed in the formulation of adhesives, sealants, and elastomers that require high-performance cross-linking under demanding conditions.
• Chemical Research & Development: Utilized in academic and industrial labs for synthesizing novel heterocyclic compounds and exploring new reaction pathways in organic synthesis.
• Liquid Crystal & Electronic Materials: Acts as an intermediate in the production of advanced materials for electronic applications, where fluorine-containing groups are advantageous.

Basic Information

Product Name	4-(Difluoromethoxy)Phenyl Isocyanate
CAS No.	58417-15-5
Molecular Formula	C8H5F2NO2
Molecular Weight	185.13 g/mol
Synonyms	p-(Difluoromethoxy)phenyl isocyanate; 1-Isocyanato-4-(difluoromethoxy)benzene; 4-Difluoromethoxyphenyl isocyanate; Isocyanic acid, 4-(difluoromethoxy)phenyl ester; Difluoromethoxyphenyl isocyanate; (4-Isocyanatophenyl)difluoromethyl ether; NSC 405124; α,α-Difluoro-p-cresyl isocyanate methyl ether
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethoxy)Phenyl Isocyanate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at temperatures between 2°C and 8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as alcohols, amines, and strong bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (by GC/HPLC)	≥ 98.0%
Water Content (Karl Fischer)	≤ 0.1%
Density (at 20°C)	~1.35 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.