Description

Diethyl 1,4-Dihydro-2,6-Dimethyl-4-(4-Fluorophenyl)-3,5-Pyridinedicarboxylate is a high-purity pharmaceutical intermediate and a key synthetic precursor for dihydropyridine-based calcium channel blockers. This compound matters for its critical role in the development and production of cardiovascular medications, offering manufacturers a reliable and consistent building block for complex active pharmaceutical ingredients (APIs). It is essential for R&D laboratories and production facilities in the pharmaceutical, fine chemical, and advanced material synthesis sectors.

Application

• Pharmaceutical Intermediate: Primary building block for the synthesis of dihydropyridine-class calcium channel antagonists (e.g., Nifedipine, Felodipine, Amlodipine analogs).
• Cardiovascular Drug Research: Used in R&D for developing new vasodilatory and antihypertensive drug candidates.
• Fine Chemical Synthesis: Serves as a versatile precursor for creating complex, functionalized pyridine derivatives in organic synthesis.
• Reference Standard: Utilized as a certified reference material (CRM) in analytical laboratories for method development and quality control of APIs.
• Process Chemistry: Employed in scale-up and optimization studies for the commercial manufacturing of target APIs.

Basic Information

Product Name	Diethyl 1,4-Dihydro-2,6-Dimethyl-4-(4-Fluorophenyl)-3,5-Pyridinedicarboxylate
CAS No.	58395-00-9
Molecular Formula	C19H22FNO4
Molecular Weight	347.38 g/mol
Synonyms	Diethyl 4-(4-Fluorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; 4-(4-Fluorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic Acid Diethyl Ester; 1,4-Dihydro-2,6-dimethyl-4-(4-fluorophenyl)-3,5-pyridinedicarboxylic Acid Diethyl Ester; Felodipine Intermediate; DHP Derivative; Hantzsch Ester Derivative; 4-Fluoro-DHP Ester; CAS 58395-00-9
EINECS	Contact for details

Quality Control

Our Diethyl 1,4-Dihydro-2,6-Dimethyl-4-(4-Fluorophenyl)-3,5-Pyridinedicarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support compliance with cGMP, ICH Q7, and relevant pharmacopeial guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.